Interaction of mucin with viologen and acetate derivatives of calix[4]resorcinols

The mucus layer acts as a selective diffusion barrier that has an important effect on the efficiency of drug delivery systems in human body. In this regard, currently nanocarriers various sizes and compositions are being widely developed to study their mucoadhesive properties i.e., ability interact with mucin. However, effective interaction composition mucin does not guarantee success due fact there is further form epithelial cells retained by calcium ions under layer. work, (porcine gastric mucin) calixarenes considered for first time. between calixarenes, complex physicochemical methods showed requires cationic fragments, binding realized anionic fragments calixarene structure. Therefore, combination different chemical groups structure nanocarrier plays role successful mucosal delivery. Taking into account wide possibilities synthetic modification macrocyclic platform, can find application across mucous barriers.